Ingrid Grozavu, Biochemistry
Year of Study: 4
Student’s Name: Ingrid Grozavu
Graduate Department: Biochemistry
Country of Residence: Canada
Why Faculty of Medicine?
I chose U of T's Faculty of Medicine because of its outstanding reputation, both in Canada and internationally. Having completed my BSc here, I saw that the Faculty of Medicine attracts top-talent students, and this was a community that I wanted to be a part of.
Why this Department?
I have always been interested in molecular biology and understanding of disease mechanisms. Biochemistry was, therefore, a perfect match!
Current Research Experience
My PhD thesis is to identify and understand new molecular mechanisms of cancer, and subsequently, find a way to correct these mechanisms. In more detail, I aim to identify new pathways of KRAS-driven carcinogenesis and to find innovative ways to target these pathways. I am investigating which proteins KRAS interacts with when it is healthy vs mutated. To do this, I am using the Mammalian Membrane Two-Hybrid (MaMTH) assay that was developed in our lab. MaMTH is suited for protein-protein interaction detection using both low-to-medium throughput array and high-throughput large-scale screening and for any plasma membrane interaction in virtually any cell line. Using MaMTH, I am mapping the dynamic interactions (i.e. healthy vs mutated) of KRAS to identify new vulnerabilities that we can next target with chemotherapeutics.
Future Education Plans and/or Career Goals
I am highly interested in medical entrepreneurship. This career path will let me use my creativity to solve issues in human disease and healthcare. I am also confident that I want to take on leadership roles later on in my career, and I believe that building a company from the ground-up will help me learn how to best-handle new initiatives, and then, how to manage large-scale organizations and projects.
Contact Ambassador Ingrid Grozavu